A grasp generally refers to an act of taking, holding or seizing firmly with (or as if with) the hand.

Grasp or GRASP may also refer to:

Software:

• Graphics Animation System for Professionals, the first multimedia animation program for the IBM PC
• GRASP (multimedia authoring software), a multimedia authoring software
• Grasp (software), a spooler for DOS and DOS/VSE
• GRASP (object-oriented design), General Responsibility Assignment Software Patterns (or Principles)
• GRASP, the previous version of Jgrasp, a graphical source code editor
• General Purpose Relativistic Atomic Structure Program, developed by Ian Grant and others for relativistic atomic structure calculations

Computer science:

• Greedy randomized adaptive search procedure
• GRASP (SAT solver), an SAT instance solver

Ships:

• USS Grasp (ARS-24), a United States Navy rescue and salvage ship
• USNS Grasp (T-ARS-51), a United States Navy rescue and salvage ship

Other uses:

• Glaciogenic Reservoir Analogue Studies Project, a collaborative project in glacially-related sedimentary systems
• Grace St. Paul's Episcopal Church or GraSP Church, an Episcopal church in Trenton, New Jersey, United States
• Great Apes Survival Project